Optimizing with the van Pelt and Uylings method
Van Pelt and Uylings published several methods of optimizing model parameters to achieve realistic fibre data distributions during neuronal development. Here, the optimization is applied for data obtained by Ger Ramakers.
An Octave (MATLAB compatible) script "vanpeltestimation.m" was created
to facilitate the optimization of model parameters for any set of
morphological network data, such as that obtained by Ger Ramakers.The second approach presented by van Pelt and Uylings (Brain and Mind, 2003) was found to be the most suitable to the information that is available. In that method, parameters of the D(t) function are estimated first. That may be done here in two ways:
- Regression to an exponential D(t) function (which may take the standard deviation into account).
- A polynomial fit followed by extracting parameters that can be used in an exponential D(t) function by comparing the polynomial function with the Taylor expansion of an exponential D(t) function.